Postdoctoral Fellow-MSH-12903-026

Job DescriptionThe candidate will be involved in human studies aimed at elucidating how HIV-1 infection alters homeostatic intestinal IgA responses to commensal bacteria, including IgA1 and IgA2 production by B cells. These studies will also determine the impact of any alteration of intestinal IgA responses in mucosal and systemic HIV-1 replication. Indeed, we hypothesize that infection-induced changes of the normal patterns of intestinal IgA production may impact HIV-1 spreading by perturbing the symbiosis between the gut immune system and the local microbiota, thereby heightening pro-inflammatory involved in the acceleration of HIV-1 replication.QualificationsPhD or MDCompensation StatementThe Mount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for this role is $73,588.00 - $80,000.00 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.SPOC-UAW Local 4100 at Icahn School of Medicine (Post Docs), 035 - Gastroenterology MSH - ISM, Icahn School of MedicineEOE Minorities/Women/Disabled/VeteransThe Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”ResponsibilitiesThe candidate will process human gut biopsies and paired blood samples from non-treated or ART (anti-retroviral therapy)-treated HIV-1 patients obtained from our collaborator, Dr. Saurabh Mehandru, to isolate total mononuclear cells. Dr. Mehandru will also provide biopsies from non-HIV-1 controls. When possible, B cells and plasma cells will be isolated from processed gut biopsies. Isolated intestinal and circulating cells will be used to perform high-throughput phenotypic, transcriptional and genomic studies aimed at gaining new insights into changes of the composition, differentiation, function and clonal architecture of gut B cell and plasma cell repertoires induced by HIV-1. In addition, the candidate will retrospectively evaluate archived data on blood viral loads from biopsied patients. They will also perform new assays to measure viral loads in gut tissues.Finally, the candidate will be involved in an additional research program aimed at evaluating the impact of gut infection by SARS-CoV-2 in the development of COVID-19. This project will follow up an already submitted study suggesting that COVID-19 patients with overt gut infection have a better prognosis compared to COVID-19 patients with no gut infection. We suspect that the tolerogenic properties of intestinal IgA responses may be implicated in this remarkable clinical observation. In the SARS-CoV-2 project, the candidate will utilize the same methodological approaches involved in the HIV-1 project.About UsStrength Through DiversityThe Mount Sinai Health System believes that diversity, equity, and inclusion are key drivers for excellence. We share a common devotion to delivering exceptional patient care. When you join us, you become a part of Mount Sinai’s unrivaled record of achievement, education, and advancement as we revolutionize medicine together. We invite you to participate actively as a part of the Mount Sinai Health System team by:

Using a lens of equity in all aspects of patient care delivery, education, and research to promote policies and practices to allow opportunities for all to thrive and reach their potential.

Serving as a role model confronting racist, sexist, or other inappropriate actions by speaking up, challenging exclusionary organizational practices, and standing side-by-side in support of colleagues who experience discrimination.

Inspiring and fostering an environment of anti-racist behaviors among and between departments and co-workers.

At Mount Sinai, our leaders strive to learn, empower others, and embrace change to further advance equity and improve the well-being of staff, patients, and the organization. We expect our leaders to embrace anti-racism, create a collaborative and respectful environment, and constructively disrupt the status quo to improve the system and enhance care for our patients. We work hard to create an inclusive, welcoming and nurturing work environment where all feel they are valued, belong and are able to advance professionally.Explore more about this opportunity and how you can help us write a new chapter in our history!“About the Mount Sinai Health System:Mount Sinai Health System is one of the largest academic medical systems in the New York metro area, with more than 43,000 employees working across eight hospitals, more than 400 outpatient practices, more than 300 labs, a school of nursing, and a leading school of medicine and graduate education. Mount Sinai advances health for all people, everywhere, by taking on the most complex health care challenges of our time — discovering and applying new scientific learning and knowledge; developing safer, more effective treatments; educating the next generation of medical leaders and innovators; and supporting local communities by delivering high-quality care to all who need it. Through the integration of its hospitals, labs, and schools, Mount Sinai offers comprehensive health care solutions from birth through geriatrics, leveraging innovative approaches such as artificial intelligence and informatics while keeping patients’ medical and emotional needs at the center of all treatment. The Health System includes approximately 7,400 primary and specialty care physicians; 13 joint-venture outpatient surgery centers throughout the five boroughs of New York City, Westchester, Long Island, and Florida; and more than 30 affiliated community health centers. We are consistently ranked by U.S. News & World Report's Best Hospitals, receiving high "Honor Roll" status, and are highly ranked: No. 1 in Geriatrics and top 20 in Cardiology/Heart Surgery, Diabetes/Endocrinology, Gastroenterology/GI Surgery, Neurology/Neurosurgery, Orthopedics, Pulmonology/Lung Surgery, Rehabilitation, and Urology. New York Eye and Ear Infirmary of Mount Sinai is ranked No. 12 in Ophthalmology. U.S. News & World Report’s “Best Children’s Hospitals” ranks Mount Sinai Kravis Children's Hospital among the country’s best in several pediatric specialties. The Icahn School of Medicine at Mount Sinai is ranked No. 14 nationwide in National Institutes of Health funding and in the 99th percentile in research dollars per investigator according to the Association of American Medical Colleges. Newsweek’s “The World’s Best Smart Hospitals” ranks The Mount Sinai Hospital as No. 1 in New York and in the top five globally, and Mount Sinai Morningside in the top 20 globally.The Mount Sinai Health System is an equal opportunity employer. We comply with applicable Federal civil rights laws and does not discriminate, exclude, or treat people differently on the basis of race, color, national origin, age, religion, disability, sex, sexual orientation, gender identity, or gender expression. We are passionately committed to addressing racism and its effects on our faculty, staff, students, trainees, patients, visitors, and the communities we serve. Our goal is for Mount Sinai to become an anti-racist health care and learning institution that intentionally addresses structural racism.”EOE Minorities/Women/Disabled/VeteransCompensation StatementMount Sinai Health System (MSHS) provides a salary range to comply with the New York City Law on Salary Transparency in Job Advertisements. The salary range for the role is $72500 - $80000 Annually. Actual salaries depend on a variety of factors, including experience, education, and hospital need. The salary range or contractual rate listed does not include bonuses/incentive, differential pay or other forms of compensation or benefits.