Scientist II

Vacancy expired!

Hello, Hope you are doing well

This is Priyanka from Experis, a ManpowerGroup company has an exciting contract opportunity for one of our key clients, a Fortune 500 American global biopharmaceutical company that is engaged in the discovery, development, and manufacture of healthcare products. I have a job very good opportunity for you, please go through the below job details and if you feel interested, please share your resume on

Position Title: Scientist II

Length of Contract: 12 months

Location/Site: Worcester, MA

Interview Process

• Please define your required Interview Process:

o 30 min MS Teams Video with HM

o Second Round: 2 to 2.5 hrs. with team

The first 30 minutes will consist of the candidates providing a seminar. The candidates typically give a seminar on their research work.

Description Details

Scientist II - New Biologics Developability Screening: Analytical and Formulation Development

Responsibilities:

• Conduct laboratory-based analytical biochemistry and formulation development activities with Biologic drug candidates. Develop fit-for-purpose methods for analytical characterization.
• Conduct experiments to evaluate physicochemical properties of new biologic entities (monoclonal antibodies, bispecific antibodies, antibody drug conjugates, fusion proteins, AAV etc.) for potential liabilities that could impact drug development.
• Independently execute experimental protocols and SOPs, collect results, and perform data analysis. Document studies and report results in group and cross-functional meetings.

Requirements:

• BS, MS, or PhD in Biophysics, Bioengineering, Chemical Engineering, Biochemistry, Pharmaceutical Sciences or related field with 3+ (BS), 1+ (MS), or 0 (PhD) years biopharmaceutical industry preferred.
• Hands-on experience in protein biochemical/biophysical characterization, formulation development, analytical method development. Strong background in protein analytical development, protein stability, degradation pathways and formulation development.
• Expertise in protein biophysical/biochemical characterization, including spectroscopy (UV-Vis, CD, analytical ultracentrifugation, fluorescence), chromatography (size exclusion, ion-exchange, reverse phase, hydrophobic interaction chromatography), electrophoresis (icIEF, CE-SDS), differential scanning calorimetry/fluorimetry, viscosity, light scattering techniques (DLS, SLS) and subvisible particle characterization. AAV and other viral gene therapy analytical experience is desired. Must be willing to learn new techniques as needed.
• A self-motivated and effective team member with excellent oral and written communication skills.

• What are the top 3-5 skills/requirements this person is required to have?

o

Required Skill 1: Ability to calculate concentrations of active and secondary components, convert between units and prepare solutions as needed. Measure and calculate protein concentration given an extinction coefficient using spectrophotometry. Understand Beer's Law and interpret absorbance spectrum.

o

Required Skill 2: Understand protein stability and degradation pathways.

o

Required Skill 3: Understand the principles of chromatography. UPLC/HPLC hands-on experience (size exclusion, ion-exchange, reverse phase, hydrophobic interaction chromatography).

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Required Skill 4: Ability to use Excel, PowerPoint, and other analysis software for basic statistical calculation and data analysis.

O Lab work experience

• What years of experience, education, and/or certification is required?

o Preferred degrees: Biophysics, Bioengineering, Chemical Engineering, Biochemistry, Pharmaceutical Sciences or related field. Experience: 3+ (BS), 1+ (MS), or 0 (PhD) years biopharmaceutical industry preferred.

• What is a nice to have (but not required) regarding skills, requirements, experience, education, or certification?

o AAV and other viral gene therapy characterization experience.

• What is the environment that this person will be working in (i.e. group setting vs. individual role)?

o Independently but in a group setting.

Vacancy expired!